Can Stress Cause Infertility?
Historically, infertility, particularly “functional” infertility, was attributed to abnormal psychological functioning on the part of one or both members of the couple. Preliminary works in the 1940s and 1950s considered “psychogenic infertility” as the major cause of failure to conceive in as many as 50% of cases. As recently as the late 1960s, it was commonly believed that reproductive failure was the result of psychological and emotional factors. Psychogenic infertility was supposed to occur because of unconscious anxiety about sexual feelings, ambivalence toward motherhood, unresolved Oedipal conflict, or conflicts of gender identity. Fortunately, advances in reproductive endocrinology and medical technology as well as in psychological research have de-emphasized the significance of psychopathology as the basis of infertility, and modern research shows that there is little evidence to support a role for personality factors or conflicts as a cause of infertility. This perspective unburdens the couple by relieving them of the additional guilt of thinking that it is their mental stress that may be responsible for their infertility.
Biologically, since the hypothalamus regulates both stress responses as well as the sex hormones, it’s easy to see how stress could cause infertility in some women. Excessive stress may even lead to complete suppression of the menstrual cycle, and this is often seen in female marathon runners, who develop ” runner’s amenorrhea”. In less severe cases, it could cause anovulation or irregular menstrual cycles. When activated by stress, the pituitary gland also produces increased amounts of prolactin, and elevated levels of prolactin could cause irregular ovulation. Since the female reproductive tract contains catecholamine receptors catecholamines produced in response to stress may potentially affect fertility, for example, by interfering with the transport of gametes through the Fallopian tube or by altering uterine blood flow.
However, more complex mechanisms may be at play, and researchers still don’t completely understand how stress interacts with the reproductive system. This is a story which is still unfolding, and during the last 20 years, the new field of pychoneuroimmunology has emerged, which focuses on how your mind can affect your body. Research has shown that the brain produces special molecules called neuropeptides, in response to emotions, and these peptides can interact with every cell of the body, including those of the immune system. In this view, the mind and the body are not only connected, but inseparable, so that it is hardly surprising that stress can have a negative influence on fertility.
Stress can reduce sperm counts as well. Thus, testicular biopsies obtained from prisoners awaiting execution, who were obviously under extreme stress, revealed complete spermatogenetic arrest in all cases. Researchers have also showed significantly lower semen volume and sperm concentration in a group of chronically stressed marmoset monkey, and these changes were attributed to lower concentrations of LH and testosterone (which were reduced in the stressed group). However, how relevant these research findings are in clinical practise is still to be determined.
In addition to these direct effects, stress can also suppress libido, cause erectile dysfunction, and result in a reduction in the frequency of intercourse, which in turn could also reduce fertility. Also, many women start overeating in response to the stress of infertility. The increased fat cells then disrupt the hormonal balance, making a bad situation even worse.
While studies have shown that infertile couples do show psychologic dysfunction and even psychiatric abnormalities ( such as depression or anxiety), this is actually a chicken and egg problem, and in reality the response of the infertile couple is a perfectly “normal” response to their abnormal situation, which is designed to help them to cope with the difficult circumstances they find themselves in. However, many people start blaming the couple, and many couples themselves start believing that it is the stress which they are under which is causing them to be infertile.
Victim blaming is popular – especially where fertility and women are concerned, and instead of providing them with support, couples receive completely gratuitous and unwanted advise. Ironically, victim blaming has become more prevalent today because of the fashionable “holistic health” belief about the influence of the mind on the body, which holds that even patients with cancer can cure themselves by the power of positive thinking. Many IVF – In Vitro Fertilization couples too may subscribe to the belief that success is practically guaranteed if the patient remain optimistic and relaxed. Thus, if the attempt fails, it was because the patient was “too tense” or ” too stressed out”.
This myth has been perpetuated by anecdotes of friends or relatives who have conceived while on holiday, and stories of couples conceiving after many years of infertility after they have adopted a baby are a part of today’s “urban myths”.
Stress and infertility often have a circular relationship, and they can aggravate each other, setting up a vicious cycle. Infertile couples, who are under stress because of their infertility, start blaming themselves for their infertility. This increases their stress levels and further aggravates the problem! As one mind-body expert has said, “Stress causes illness causes more stress which causes more illness.”
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